The Global 3D Cell Culture Market size is expected to reach $3.2 billion by 2028, rising at a market growth of 15.4% CAGR during the forecast period.
A 3D cell culture is an artificial environment that allows biological cells to grow or communicate with their surroundings in three dimensions. A 3D cell culture, as opposed to 2D surroundings (such as a Petri plate), permits cells in vitro to develop in all directions, as they would in vivo. Typically, these three-dimensional cultures are cultivated in bioreactors, which are tiny capsules in which cells can form spheroids or 3D cell colonies.
Per bioreactor, approximately 300 spheroids are typically grown. Microfluidic equipment generating perfusable 3D tissues and hanging drop devices for generating 3D spheroids can also be used to cultivate 3D cell cultures. Researchers have utilized 3D cell cultures for decades.
The significance of the extracellular matrix and the capacity of cultures in artificial 3D matrices to generate physiologically appropriate multicellular structures, such as acinar structures in models of healthy and malignant breast tissue have been studied by a number of researchers during the initial development of 3D cell culture.
These techniques have been utilized to investigate cellular responses to pharmacological substances using in vitro illness models. In live tissue, cells dwell in three-dimensional microenvironments characterized by intricate cell-cell as well as cell-matrix interactions along with complex nutrition and cell transport dynamics. Standard 2D or monolayer cell cultures are generally inaccurate predictors of in vivo drug toxicity and efficacy because they do not adequately replicate this environment.
Airway and air-liquid interface organoids have been utilized as tools for the research and development of antiviral medicines, as well as experimental virology platforms for the investigation of the immune response and infectiousness of SARS-CoV-2. Both scaffold-based and scaffold-free strategies enable the bio-fabrication of realistic simulation that can be leveraged to create innovative treatments and vaccines for COVID-19. In addition to the launch of new products and the extensive use of 3D protocols in biological research, a number of other significant factors are driving the market's expansion.
Recent developments in microfluidics in 3D cell culture have enabled the development of microenvironments that promote tissue differentiation and imitate the tissue-tissue interface, chemical gradients, and spatiotemporal as well as mechanical microenvironments of real organs. This 3D cell culture model enables the study of human physiology within an accordion setting, facilitates the development of in vitro disease models, and will eventually replace animal models in drug development along with toxicity assessment.
During the early stages of drug development, animal models were the only way to acquire in vivo data that could anticipate human pharmacokinetic effects. However, animal testing is slow, expensive, and controversial. Frequently, animal models are subjected to mechanical or chemical techniques that mimic human damage. Concerns exist regarding the accuracy of these animal models due to the absence of interspecies extrapolation.
The use of scaffolds to support three-dimensional cultures of cells has broadened the scope of research possibilities. However, the existence of various growth factors in scaffolds causes their variability from batch to batch. This makes it difficult to conduct biological research on signaling pathways or pharmacological examinations. The proliferation rate remained extremely high, despite the fact that the cells grown on scaffolds with low levels of growth factors had phenotypes that were comparable to those of cells grown on scaffolds with high levels of growth factors.
On the basis of Type, the 3D Cell Culture Market is segmented into Scaffold-based, Scaffold-free, Microfluidics-based, and Magnetic & Bioprinted. In 2021, the scaffold-based 3D cell cultures segment acquired the largest revenue share of the 3D cell culture market. Scaffold-based 3D cell cultures are preferred due to their structural rigidity, the accessibility of attachment places, and their support.
Based on Application, the 3D Cell Culture Market is segregated into Cancer & Stem Cell Research, Drug Discovery & Toxicology Testing, and Tissue Engineering & Regenerative Medicine. In 2021, the drug discovery & toxicology testing segment registered a substantial revenue share of the 3D cell culture market. The increasing growth of the segment can be linked to the increase in demand for novel therapeutic drugs throughout the world, which are used to treat a wide variety of illnesses.
By End-User, the 3D Cell Culture Market is categorized into Pharmaceutical & Biotechnology Companies, Research Institutes, Cosmetics Industry, and Other End Users. In 2021, the pharmaceutical and biotechnology companies segment procured the largest revenue share of the 3D cell culture market. In the pharmaceutical industry, cell-based assays and 3D cell models have proven to be an effective tool for evaluating the impact of external stimuli and pharmacological drugs on overall cellular activity.
| Report Attribute | Details |
|---|---|
| Market size value in 2021 | USD 1.2 Billion |
| Market size forecast in 2028 | USD 3.2 Billion |
| Base Year | 2021 |
| Historical Period | 2018 to 2020 |
| Forecast Period | 2022 to 2028 |
| Revenue Growth Rate | CAGR of 15.4% from 2022 to 2028 |
| Number of Pages | 227 |
| Number of Tables | 374 |
| Report coverage | Market Trends, Revenue Estimation and Forecast, Segmentation Analysis, Regional and Country Breakdown, Competitive Landscape, Companies Strategic Developments, Company Profiling |
| Segments covered | Type, Application, End User, Region |
| Country scope | US, Canada, Mexico, Germany, UK, France, Russia, Spain, Italy, China, Japan, India, South Korea, Singapore, Malaysia, Brazil, Argentina, UAE, Saudi Arabia, South Africa, Nigeria |
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| Restraints |
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Region-Wise, the Artificial Intelligence in Medical Diagnostics Market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. In 2021, North America accounted for the highest revenue share of the AI in medical diagnosis market. The growth of North American AI in the medical diagnostics market is primarily driven by technological advancements, an increasing number of fresh product approvals, an increasing adoption rate of artificial intelligence in healthcare, the presence of key market players, and an established IT infrastructure within the healthcare sector.
Free Valuable Insights: Global 3D Cell Culture Market size to reach USD 3.2 Billion by 2028
The major strategies followed by the market participants are Product Launches and Partnerships. Based on the Analysis presented in the Cardinal matrix; Thermo Fisher Scientific, Inc. are the forerunners in the 3D Cell Culture Market. Companies such as Corning Incorporated Lonza Group AG and Merck Group are some of the key innovators in 3D Cell Culture Market.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Thermo Fisher Scientific, Inc., Merck Group, Avantor, Inc., Corning Incorporated, Lonza Group AG, Mimetas B.V., Insphero AG, Emulate, Inc., Tecan Group Ltd., and CN Bio Innovations Ltd.
By Type
By Application
By End User
By Geography
The 3D Cell Culture Market size is projected to reach USD 3.2 billion by 2028.
The Development Of 3d Cell Culture Based On Microfluidics are driving the market in coming years, however, The Dearth Of Consistency In Products Being Developed Through 3d Cell Culture restraints the growth of the market.
Thermo Fisher Scientific, Inc., Merck Group, Avantor, Inc., Corning Incorporated, Lonza Group AG, Mimetas B.V., Insphero AG, Emulate, Inc., Tecan Group Ltd., and CN Bio Innovations Ltd.
The expected CAGR of the 3D Cell Culture Market is 15.4% from 2022 to 2028.
The Cancer & Stem Cell Research segment is leading the Global 3D Cell Culture Market by Application in 2021 thereby, achieving a market value of $1.5 billion by 2028.
The North America market dominated the Global 3D Cell Culture Market by Region in 2021, and would continue to be a dominant market till 2028; thereby, achieving a market value of $1.2 billion by 2028.
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